Figure 2.

This figure shows the functions of acute inflammation-induced sickness behavior: a) energy saving by protecting the organism from the energy consuming effects of inflammation (through somnolence, lethargy, sleepiness, hyperalgesia, reduction of motor activity, exploration and grooming, cognitive deficits, loss of libido, anhedonia, disinterest in social interactions with the environment, and anxiety); b) anti-inflammatory effects (through anorexia, weight loss); and c) pathogen-directed effects (through pyrexia).

Maes et al. BMC Medicine 2012 10:66   doi:10.1186/1741-7015-10-66
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