Open Access Research article

Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population

James K Ellis1, Toby J Athersuch12, Laura DK Thomas34, Friederike Teichert5, Miriam Pérez-Trujillo7, Claus Svendsen6, David J Spurgeon6, Rajinder Singh5, Lars Järup23, Jacob G Bundy12 and Hector C Keun12*

Author Affiliations

1 Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, UK

2 MRC-HPA Centre for Environment and Health, Imperial College London, W2 1PG, UK

3 Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK

4 Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

5 Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, LE2 7LX, UK

6 Centre for Ecology and Hydrology, Maclean Building, Benson Lane, Crowmarsh Gifford, Wallingford, Oxon, OX10 8BB, UK

7 Servei de Ressonància Magnètica Nuclear, SeRMN, Universitat Autònoma de Barcelona, Barcelona, Spain

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BMC Medicine 2012, 10:61  doi:10.1186/1741-7015-10-61

Published: 19 June 2012

Additional files

Additional file 1:

Supporting information for metabolite identification and PLS model validity. The additional file includes NMR spectroscopic data that were acquired to elucidate the structure of an unknown urinary metabolite, details of samples excluded from the multivariate analysis and validation and scores plots of the PLS models.

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