Table 2

Distribution of the genotype in selected SNPs of MMR genes

Gene

tSNP

Controls MAF

Case1a MAF

Pc

Case2b

MAF

Pc


MLH1

rs1799977

0.023

0.028

0.628

0.025

0.828

rs4647269

0.047

0.075

0.032

0.067

0.175

rs1540354

0.304

0.343

0.326

0.331

0.428

PMS2

rs3815383

0.332

0.332

0.923

0.342

0.816

rs2286680

0.074

0.080

0.772

0.089

0.491

rs11769380

0.410

0.419

0.816

0.379

0.736

rs1059060

0.091

0.146

0.003

0.170

2.0 × 10-4

rs2228006

0.063

0.054

0.520

0.056

0.582

MLH3

rs13712

0.184

0.185

0.913

0.185

0.962

rs7156586

0.222

0.217

0.832

0.406

0.527

rs175049

0.185

0.173

0.646

0.177

0.727

MSH4

rs1021462

0.309

0.336

0.592

0.317

0.842

MSH5

rs3749953

0.121

0.154

0.278

0.148

0.653

rs1150793

0.142

0.141

0.960

0.138

0.827

rs707939

0.359

0.337

0.582

0.357

0.886

rs707938

0.304

0.331

0.557

0.336

0.231

rs3115672

0.375

0.402

0.681

0.377

0.929

rs3117572

0.223

0.206

0.724

0.231

0.782

rs2299850

0.063

0.056

0.652

0.068

0.720

rs9461718

0.144

0.161

0.472

0.157

0.567

rs2075789

0.081

0.139

0.002

0.097

0.485


Abbreviations: MAF, minor allele frequency.

aCase 1: idiopathic infertile men with azoospermia or oligozoospermia.

bCase 2: idiopathic infertile men with normal sperm count.

Data in bold highlights the statistic significant results.

cFalse Discovery Rate (FDR) corrected P-value.

Data in boldface represent P < 0.05.

Ji et al. BMC Medicine 2012 10:49   doi:10.1186/1741-7015-10-49

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