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Open Access Research article

Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility

Guixiang Ji123, Yan Long4, Yong Zhou5, Cong Huang12, Aihua Gu12* and Xinru Wang12*

Author Affiliations

1 State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, 210029, China

2 Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 210029, China

3 Nanjing Institute of Environmental Sciences/Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Ministry of Environmental Protection, Nanjing 210042, China

4 China Pharmaceutical University, Department of Pharmacology, Nanjing 210024, China

5 Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine

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BMC Medicine 2012, 10:49  doi:10.1186/1741-7015-10-49

Published: 17 May 2012

Additional files

Additional file 1:

Additional file 1. Primer Sequences for SNPstream Genotyping and TaqMan analysis.

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Additional file 2:

Additional file 2. Information on genotyped tSNPs of the MMR genes evaluated in this study.

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Additional file 3:

Additional file 3. Effect of cryopreservation on sperm DNA fragmentation.

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Additional file 4:

Additional file 4 (Figure S). Schematic diagram of the recombinant plasmids containing the potential MLH1-PMS2 interaction domain in the fluorescence resonance energy transfer (FRET) assay.

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