Email updates

Keep up to date with the latest news and content from BMC Medicine and BioMed Central.

Journal App

google play app store
Open Access Research article

Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores

Nobutake Yamamichi*, Satoshi Mochizuki, Itsuko Asada-Hirayama, Rie Mikami-Matsuda, Takeshi Shimamoto, Maki Konno-Shimizu, Yu Takahashi, Chihiro Takeuchi, Keiko Niimi, Satoshi Ono, Shinya Kodashima, Chihiro Minatsuki, Mitsuhiro Fujishiro, Toru Mitsushima and Kazuhiko Koike

BMC Medicine 2012, 10:45  doi:10.1186/1741-7015-10-45

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email info@biomedcentral.com, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

Do hypnotics cause GERD?

Daniel Kripke   (2012-06-11 11:39)  UCSD

The strong association of reported sleep disturbance with GERD is interesting. Gagliardi et al. [1] showed experimentally that zolpidem caused GERD. More recently, my colleagues and I [2] found an association of hypnotic usage with both esophageal-gastric complaints and esophageal cancer. Thus, it seems important to determine if hypnotics were the underlying cause of GERD associated with "inadequate sleep" in this study. Can the authors comment?

[1] Gagliardi, G. S., Shah, A. P., Goldstein, M., Denua-Rivera, S., Doghramji, K., Cohen, S., and Dimarino, A. J., Jr. Effect of Zolpidem On the Sleep Arousal Response To Nocturnal Esophageal Acid Exposure. Clin Gastroenterol.Hepatol. 7(9), 948-952. 5-6-2009.

[2] Kripke, D. F., Langer, R. D., and Kline, L. E. Hypnotics' association with mortality or cancer: a matched cohort study. BMJ Open. 2(1), e000850. 2012 and "Web Extra" data supplement.

Competing interests

None.

top

Post a comment