Open Access Research article

Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model

Bob JH van Kempen12, Bart S Ferket12, Albert Hofman1, Ewout W Steyerberg3, Ersen B Colkesen6, S Matthijs Boekholdt5, Nicholas J Wareham7, Kay-Tee Khaw8 and MG Myriam Hunink124*

Author Affiliations

1 Department of Epidemiology, Erasmus MC Rotterdam, dr Molewaterplein 50, Rotterdam, 3015 GE, the Netherlands

2 Department of Radiology, Erasmus MC Rotterdam, dr Molewaterplein 50, Rotterdam, 3015 GE, the Netherlands

3 Department of Public Health, Erasmus MC Rotterdam, dr Molewaterplein 50, Rotterdam, 3015 GE, the Netherlands

4 Department of Health Policy and Management, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA

5 Department of Cardiology, Amsterdam Medical Center, Meibergdreef 9, Amsterdam, 1150 AZ, the Netherlands

6 Department of Cardiology, Antonius Hospital, Koekoekslaan 1, Nieuwegein, 3435 CM, the Netherlands

7 Medical Research Council Epidemiology Unit, Hills Road, Cambridge, CB2 0QQ, UK

8 Department of Public Health and Primary Care, University of Cambridge, Robinson Way, Cambridge, CB2 0SR, UK

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BMC Medicine 2012, 10:158  doi:10.1186/1741-7015-10-158

Published: 6 December 2012

Additional files

Additional file 1:

Technical appendix. Technical appendix with additional information on the Rotterdam Ischemic Heart Disease and Stroke Computer Simulation (RISC) model and analyses.

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