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Personalized medicine and atrial fibrillation: will it ever happen?

Steven A Lubitz* and Patrick T Ellinor

Author Affiliations

Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA

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BMC Medicine 2012, 10:155  doi:10.1186/1741-7015-10-155

Published: 4 December 2012

Abstract

Atrial fibrillation (AF) is a common arrhythmia of substantial public health importance. Recent evidence demonstrates a heritable component underlying AF, and genetic discoveries have identified common variants associated with the arrhythmia. Ultimately one hopes that the consideration of genetic variation in clinical practice may enhance care and improve health outcomes. In this review we explore areas of potential clinical utility in AF management including those relating to pharmacogenetics and risk prediction.

Keywords:
Atrial fibrillation; genetics; personalized medicine; risk prediction; pharmacogenetics