Table 6

Biologic pathways that distinguish or are shared between SJIA ESR and POLY ESR

IPA Canonical Pathways

-Logarithm

(P-value)

Difference

(SJIA-POLY)

Gene expression with higher

SJIA ESR/

POLY ESR

SJIA ESR

POLY ESR

IL-10 signaling

8.56

4.22

4.34

Higher (both)

Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis

6.80

1.14

5.65

Higher (both)

Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis

5.84

0.82

5.01

Higher (both)

Glucocorticoid receptor signaling

5.68

1.34

4.34

Higher (both)

B cell receptor signaling

5.60

2.07

3.53

Higher (both)

Role of PKR in interferon induction and antiviral response

4.43

0.86

3.56

Higher (both)

Systemic lupus Erythematosus signaling

4.08

0.46

3.62

Higher (both)

altered T cell and B cell signaling in rheumatoid arthritis

3.91

1.34

2.57

Higher (both)

A proliferation-inducing ligand mediated signaling

3.80

0.95

2.86

Lower (both)

IL-15 signaling

3.76

0.76

3.01

Lower (both)

T helper cell differentiation

3.74

0.00

3.74

Lower (both)

iCOS-iCOSL signaling in T helper cells

3.73

0.51

3.22

Lower (both)

CD40 signaling

3.73

0.75

2.98

Lower (both)

B cell activating factor signaling

3.70

0.93

2.77

Lower (both)

Dendritic cell maturation

3.65

0.94

2.71

Higher (both)

IL-12 signaling and production in macrophages

3.08

0.52

2.55

Lower (both)

p38 MAPK signaling

3.08

0.52

2.55

Higher (both)

PPAR alpha/RXR alpha activation

2.96

0.42

2.55

Higher (both)

* in ≥ 50% of the genes in the pathway; in comparison to lower SJIA ESR/POLY ESR.

Ling et al. BMC Medicine 2012 10:125   doi:10.1186/1741-7015-10-125