Table 5

Biologic pathways that distinguish or are shared between SJIA ESR and SJIA JC

IPA Canonical Pathways

-Logarithm

(P-value)

Difference

(ESR-JC)

Gene expression with higher ESR/JC*


SJIA ESR

SJIA JC


Glucocorticoid receptor signaling

5.68

3.07

2.61

Higher (both)


PI3K/AKT signaling

1.27

3.73

-2.45

Higher (both)


Role of PKR in interferon induction and antiviral response

4.43

4.43

0

Higher (both)


Altered T cell and B cell signaling in rheumatoid arthritis

3.91

3.91

0

Higher (both)


T helper cell differentiation

3.74

3.74

0

Lower (both)


iCOS-iCOSL signaling in T helper cells

3.73

3.73

0

Lower (both)


CD40 signaling

3.73

3.73

0

Lower (both)


MIF regulation of innate immunity

3.70

3.70

0

Higher (both)


LPS-stimulated MAPK signaling

3.42

3.42

0

Higher (both)


CD27 signaling in lymphocytes

3.18

3.18

0

Higher (both)


MIF-mediated glucocorticoid regulation

3.02

3.02

0

Higher (both)


Role of cytokines in mediating communication between immune cells

3.01

3.01

0

Higher (both)


TREM1 signaling

2.91

2.91

0

Higher (both)


Crosstalk between dendritic cells and natural killer cells

2.81

2.81

0

Lower (both)


Docosahexaenoic acid (DHA) signaling

2.76

2.76

0

Higher (both)


Regulation of IL-2 expression in activated and anergic T lymphocytes

2.39

2.39

0

Higher (both)


Toll-like receptor signaling

2.37

2.37

0

Lower (both)


fMLP signaling in neutrophils

2.33

2.33

0

Higher (both)


TNFR1 signaling

2.22

2.22

0

Higher (both)


RANK signaling in osteoclasts

2.16

2.16

0

Lower (both)


4-1BB signaling in T lymphocytes

2.12

2.12

0

Higher (both)


CD28 signaling in T helper cells

2.11

2.11

0

Lower (both)


Communication between innate and adaptive immune cells

2.06

2.06

0

Higher (both)


T cell receptor signaling

2.03

2.03

0

Lower (both)


ILK signaling

2.01

2.01

0

Higher (both)


* in ≥ 50% of the genes in the pathway; in comparison to lower ESR/JC.

Ling et al. BMC Medicine 2012 10:125   doi:10.1186/1741-7015-10-125

Open Data