Figure 4.

Analysis of JC-associated genes in SJIA patients with high JC counts but different systemic scores. (A) Distribution analysis of SJIA patients, according to both joint count (JC) and systemic scores, established systemic plus arthritis flare (SAF) and arthritis flare (AF) subgroups. (B) Pearson correlation analysis relating JC values to the associated gene expression in both the SAF and AF subgroups. (C) Pathway analysis of the JC correlated genes in AF subgroup. Differentially JC-correlated genes were analyzed using data mining software (Ingenuity Systems) to identify relevant biological pathways associated with each clinical subgroup. The node color indicates the degree of positive (red) or negative (green) correlation to SJIA AF. Nodes are displayed using shapes that represent the functional class of the gene product and different relationships are represented by line type (see legend). Relationships are primarily due to co-expression, but can also include phosphorylation/dephosphorylation, proteolysis, activation/deactivation, transcription, binding, inhibition, biochemical modification.