Schematic representation of the HIV-1 protease wireframe crystal structure and highlighting the secondary/compensatory selected under protease inhibitor treatment. (A) The wireframe cartoon of the protease X-ray crystal structure (PDB ID:3HVP ) is present to highlight the position of the secondary mutations (black dots) that compensate for fitness losses derived from primary drug resistance to protease inhibitors (red dots). (B) A schematic representation of the genetic diversity in the HIV-1 protease derived from the curated HIV-1 protease alignment from Los Alamos National Laboratories HIV sequence database. Alignments of protease and any amino acid found at >1% frequency is presented in this WebLogo (http://weblogo.berkeley.edu webcite).
Arts BMC Medicine 2012 10:114 doi:10.1186/1741-7015-10-114