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The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA

Philipp Kapranov1*, Georges St Laurent28, Tal Raz1, Fatih Ozsolak1, C Patrick Reynolds3, Poul HB Sorensen4, Gregory Reaman5, Patrice Milos1, Robert J Arceci6, John F Thompson1* and Timothy J Triche7*

Author affiliations

1 Helicos BioSciences Corporation, One Kendall Square, Building 700, Cambridge, MA 02139, USA

2 Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, SFH Life Sciences Building, 185 Meeting St, Providence, RI 02912, USA

3 Cancer Center, Departments of Cell Biology & Biochemistry, Pediatrics, and Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, 3601 4th Street STOP 9445, Lubbock, TX 79430-6450, USA

4 British Columbia Cancer Research Centre, 675 West 10th Avenue, Room 4112, Vancouver, BC, Canada V5Z 1L3

5 Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Division of Oncology, Children's National Medical Center, 11 Michigan Ave, NW, Washington, DC, 20422, USA

6 Kimmel Comprehensive Cancer Center at John Hopkins, Department of Oncology/Pediatric Oncology, The Buntings Blaustein Cancer Research Building, 1650 Orleans Street, Suite 207, Baltimore, MD, 21287, USA

7 Department of Pathology, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90089-9034, USA

8 Grupo de Inmunovirologia, SIU, Universidad de Antioquia, Calle 67 Número 53 - 108, Medellin, Antioquia, Colombia

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Citation and License

BMC Biology 2011, 9:86  doi:10.1186/1741-7007-9-86

Published: 20 December 2011

First paragraph (this article has no abstract)

The publisher notes typographical errors which were introduced to the first paragraph of page 10 (beginning "Previously, human large intergenic non-coding (linc) RNAs were identified in normal human embryonic and stem cell lines...") during the production process. The publisher apologises for the errors caused. The online article HTML was corrected on 19 October 2011, and the article PDF on 31 October 2011; readers with previous versions of the article are advised to update to the corrected version [1].