Figure 1.

Schematic representation of protein degradation by the proteasome. Proteins are tagged for degradation by regulated ubiquitylation, which directs them to binding sites on the 19S regulatory subunits where they are unfolded for degradation in the barrel-shaped 20S catalytic core.

Chauhan and Anderson BMC Biology 2011 9:72   doi:10.1186/1741-7007-9-72
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