Table 1

Genetic interaction between Myc and components of insulin and target of rapamycin signaling.

Genotype

Total number ommatidia

Ommatidium cell size (μm2)

% numbera

%

cell sizeb


ey- dm+ /Y; +/+; +/+

726 ± 17 (15)

239 ± 14 (15)

100

100


ey- dm+ /Y; UAS-Dp110/+

811 ± 31 (06) *

329 ± 10 (06) *

112

138


ey- dm+ /Y; UAS-PTEN/+

538 ± 25 (13) *

220 ± 11 (09) *

074

092


ey- dm+ /Y; UAS-S6K/+

692 ± 37 (10) **

251 ± 12 (11) **

095

105


ey- dm+ /Y; UAS- Rheb-AV4 /+

555 ± 18 (06) *

452 ± 19 (06) *

076

189


ey- dm+ /Y; UAS-TOR-TED /+

579 ± 55 (11) *

214 ± 13 (11) *

080

089


ey- dmP0/Y; +/+; +/+

735 ± 16 (12)

218 ± 09 (12)

100

100


ey- dm P0/Y; UAS-Dp110/+

703 ± 41 (06) **

293 ± 12 (06) *

096

135


ey- dm P0 /Y; UAS-PTEN/+

450 ± 16 (06) *

140 ± 09 (06) *

061

064


ey- dm P0 /Y; UAS-S6K/+

684 ± 35 (09) *

216 ± 15 (13)

093

099


ey- dmP0 /Y; UAS- Rheb-AV4 /+

651 ± 31 (07) *

335 ± 09 (09) *

088

154


ey- dm P0/Y; UAS-TOR-TED /+

n.d.

n.d.

n.d.

n.d.


ey- dm4/Y; +/+; +/+

650 ± 44 (17)

179 ± 11 (10)

100

100


ey- dm4/Y; UAS-Dp110/+

641 ± 66 (11)

228 ± 08 (06) *

100

127


ey- dm4/Y; UAS-PTEN/+

458 ± 42 (06) *

120 ± 13 (06) *

070

067


ey- dm4/Y; UAS- Rheb-AV4 /+

647 ± 29 (12)

238 ± 22 (08) *

100

132


ey- dm4 /Y; UAS-TOR-TED /+

n.d.

n.d.

n.d.

n.d.


Standard deviations (±) are calculated based on the total number of the animals (reported in parenthesis); aPercentage of increase in size compared to relative control (100); b Percentage increase in cell number compared to relative control (100); p-values calculated using a Student t test: * P < 0.001; ** P < 0.05; n.d. = not determined. Of note: overexpression of PTEN in ey-dmP0/Y animals resulted in a misshaped eye phenotype (Figure 4A, Panel c') with a 98% penetrance, which might have led to an underestimation of the total number of ommatidia and therefore affected our statistical analysis.

Parisi et al. BMC Biology 2011 9:65   doi:10.1186/1741-7007-9-65

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