Correspondence: Sean Munro firstname.lastname@example.org
BMC Biology 2011, 9:63 doi:10.1186/1741-7007-9-63
(2011-11-08 17:15) MRC-LMB
It is interesting to speculate on the origin of the machinery for forming membrane
stacks, but there is no evidence at present that thylakoids and the Golgi use related
components for their structure. However, the radiolabeling of proteins to follow
their route through the secretory pathway was precisely the method used by George
Palade to first demonstrate that secreted proteins move through the Golgi after being
made in the ER. This work is described in (Caro and Palade (1964) J Cell Biol 20,473-95)
and was mentioned in Palade's Nobel Prize citation along with his discovery of the
endoplasmic reticulum and ribosomes.
(2011-10-31 16:56) College of the Marshall Islands
Two thoughts occurred to me as I read this very interesting article. First, as I looked
at Figure 3, the stacks of Golgi cisternae as depicted reminded me of the stack of
thylakoids in chloroplasts. Knowing that there is redundacy in nature as well as the
use of slightly tweaked versions of molecules from one system or process in another
system or process, i.e. NADH and NADPH in respiration and photosynthesis, respectively;
is it be possible that communication and/or transport between cisternae in Golgi is
similar to that found in the grana stacks of chloroplasts? Second thought: Has the
technology been developed to enable researchers to radioactively label, say a cell
membrane protein, made in the ER and then follow it along its journey from the ER,
through the Golgi to where its transported to the cell membrane?
None, just curiousity!
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