Tracing lineages to uncover neuronal identity
1 Ludwig Institute for Cancer Research Ltd, Box 240, 171 77 Stockholm, Sweden
2 Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden
BMC Biology 2011, 9:51 doi:10.1186/1741-7007-9-51Published: 19 July 2011
Many previous studies have focused on understanding how midbrain dopamine neurons, which are implicated in many neurological conditions, are generated during embryogenesis. One of the remaining questions concerns how different dopamine neuron subtypes are specified. A recent paper in Neural Development has revealed features of a spatial and temporal lineage map that, together with other studies, begins to elucidate the developmental origin of distinct neuronal subtypes within the developing midbrain.