MPSI caused dose-dependent, gender-specific abnormalities in adult offspring behaviour and adiposity, but no abnormalities in systolic blood pressure (SBP). (A) Reduced jumping and rearing open-field activity in male, but not female, offspring from 150 μg/kg LPS dams. (B) Increased SBP in male offspring from 10 μg/kg LPS dams. (C) Increased fat pad to body weight ratio (%) and BMI in male offspring from 150 μg/kg LPS dams. All values represent means ± SEM. *P ≤ 0.05 vs. control independent of maternal origin and litter size (n = 6 mothers per treatment; n = 18 male and 18 female offspring per treatment).
Williams et al. BMC Biology 2011 9:49 doi:10.1186/1741-7007-9-49