Open Access Research article

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

Alexei V Korennykh125*, Pascal F Egea26, Andrei A Korostelev3, Janet Finer-Moore2, Robert M Stroud2, Chao Zhang14, Kevan M Shokat14 and Peter Walter12

Author Affiliations

1 Howard Hughes Medical Institute, University of California, San Francisco, 600 16th Street, Room S272, Box 0724, San Francisco, CA 94158, USA

2 Department of Biochemistry and Biophysics, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158, USA

3 Department of Biochemistry and Molecular Pharmacology and RNA Therapeutics Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA

4 Department of Cellular and Molecular Pharmacology, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158, USA

5 Department of Molecular Biology, Princeton University, 216 Schultz Laboratory, Princeton, NJ 08544, USA

6 Department of Biological Chemistry, University of California, Los Angeles, 310 BSRB, Los Angeles, CA 90095, USA

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BMC Biology 2011, 9:48  doi:10.1186/1741-7007-9-48

Published: 6 July 2011

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Supplementary figures, tables and analyses.

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