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Open Access Highly Accessed Commentary

Robustness and fault tolerance make brains harder to study

Shyam Srinivasan1 and Charles F Stevens2*

Author Affiliations

1 2200 Gross Hall, University of California, Irvine, CA 92697, USA

2 The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

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BMC Biology 2011, 9:46  doi:10.1186/1741-7007-9-46

Published: 29 June 2011

Abstract

Brains increase the survival value of organisms by being robust and fault tolerant. That is, brain circuits continue to operate as the organism needs, even when the circuit properties are significantly perturbed. Kispersky and colleagues, in a recent paper in Neural Systems & Circuits, have found that Granger Causality analysis, an important method used to infer circuit connections from the behavior of neurons within the circuit, is defeated by the mechanisms that give rise to this robustness and fault tolerance.

See research article: http://www.neuralsystemsandcircuits.com/content/1/1/9/abstract webcite