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Open Access Commentary

Selecting synaptic partners: GRASPing the role of UNC-6/netrin

QueeLim Ch'ng

Author Affiliations

MRC Centre for Developmental Neurobiology, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK

BMC Biology 2011, 9:43  doi:10.1186/1741-7007-9-43

Published: 10 June 2011


Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.

See Research article: webcite