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Open Access Highly Accessed Commentary

Following autophagy step by step

Tom Egil Hansen and Terje Johansen*

Author affiliations

Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway

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Citation and License

BMC Biology 2011, 9:39  doi:10.1186/1741-7007-9-39

Published: 2 June 2011

Abstract

Autophagy is an evolutionarily conserved lysosomal degradation route for soluble components of the cytosol and organelles. There is great interest in identifying compounds that modulate autophagy because they may have applications in the treatment of major diseases including cancer and neurodegenerative disease. Hundeshagen and colleagues describe this month in BMC Biology a screening assay based on flow cytometry that makes it possible to track distinct steps in the autophagic process and thereby identify novel modulators of autophagy.

See research article: http://www.biomedcentral.com/1741-7007/9/38 webcite