Essentially normal basic behavior of cEPOR TG mice contrasts the distinctly superior cognitive performance. TG mice were normal in basic behavioral functions (A - E) except for slight hyperactivity, as demonstrated by increased velocity in the open field (inset B). In basic cognitive tasks, that is spatial learning/memory and cognitive flexibility as evaluated by Morris water maze (F - H) and social memory (I), cEPOR TG mice were significantly superior to WT. WT n = 18; TG n = 13; mean ± SEM presented. Insets in F: within - day learning on day one of the hidden platform task: all four trials presented; probe trial expressed as % of time spent in target quadrant; Inset in H: within-day learning on day one of the reversal task: all four trials presented.
Sargin et al. BMC Biology 2011 9:27 doi:10.1186/1741-7007-9-27