All intermediate filaments have essential structural features in common. A schematic molecular model of a coiled-coil dimer is shown for human lamin A (upper part) and human keratins 5 and 14, which heterodimerize to assemble into the keratin filament (lower part). The two molecular complexes are aligned with respect to coil 2. NLS, nuclear localization signal; pb, paired bundle; L1, linker L1; L12, linker L12; st, stutter (adapted from ).
Herrmann and Strelkov BMC Biology 2011 9:16 doi:10.1186/1741-7007-9-16