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Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus

Helen J Blair1, Stuart Tompson12, Yu-Ning Liu1, Jennifer Campbell1, Katie MacArthur1, Chris P Ponting3, Victor L Ruiz-Perez4 and Judith A Goodship1*

Author Affiliations

1 Institute of Human Genetics, Newcastle University, Centre for Life, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK

2 Medical Genetics Institute, Cedars-Sinai Medical Center 8727 West Third Street, Suite 203, Los Angeles, CA 90048, USA

3 MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK

4 Instituto de Investigaciones Biomédicas de Madrid (CSIC-UAM) and Ciber de enfermedades raras (Ciberer), Arturo Duperier, 4, 28029, Madrid, Spain

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BMC Biology 2011, 9:14  doi:10.1186/1741-7007-9-14

Published: 28 February 2011

Additional files

Additional file 1:

A phylogenetic tree of EVC and EVC2 sequences. The tree was constructed with the Fitch-Margoliash algorithm using a Poisson genetic distance and global optimization with bootstrapping. Bootstrap values at internal nodes not supported at 100% are provided. Species abbreviations: Bf, Branchiostoma floridae; Hs, Homo sapiens; Lg, Lottia gigantea; Mm, Mus musculus; Nv, Nematostella vectensis; T, Trichoplax adhaerens; Tr, Tetraodon nigroviridis; and, Xt, Xenopus tropicalis.

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