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Open Access Highly Accessed Commentary

The global dynamics of RNA stability orchestrates responses to cellular activation

Jack D Keene

Author Affiliations

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA

BMC Biology 2010, 8:95  doi:10.1186/1741-7007-8-95

Published: 8 July 2010

Abstract

Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. These changes arise from the opposing fluxes of transcription and mRNA decay, both of which affect the functional dynamics of global gene expression. A study published recently in BMC Genomics focuses on the contribution made by mRNA stability in shaping the kinetics of gene responses in mammalian cells.

See research article http://www.biomedcentral.com/1471-2164/11/259 webcite