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Altered metabolism in cancer

Jason W Locasale12* and Lewis C Cantley12

Author Affiliations

1 Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA

2 Beth Israel Deaconess Medical Center, Department of Medicine, Division of Signal Transduction, Boston, MA 02215, USA

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BMC Biology 2010, 8:88  doi:10.1186/1741-7007-8-88

Published: 25 June 2010


Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs.

See research article: webcite