Many proteins affect iron metabolism within mitochondria. Members of the mitoferrin family (orange cylinder) mediate iron import into mitochondria. Frataxin family members (green hexagons) bind iron and help deliver it to proteins that assemble Fe-S clusters (purple shape). Other mitochondrial proteins involved in respiration (not shown) incorporate the Fe-S clusters as cofactors. Mitochondrial ferritin (blue circles) and frataxin both contribute to iron sequestration and protection from oxidative damage.
Hales BMC Biology 2010 8:79 doi:10.1186/1741-7007-8-79