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Open Access Highly Accessed Commentary

The (r)evolution of cancer genetics

Francesca D Ciccarelli

Author Affiliations

Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Via Adamello 16, 20139 Milan, Italy

BMC Biology 2010, 8:74  doi:10.1186/1741-7007-8-74

Published: 11 June 2010

Abstract

The identification of an increasing number of cancer genes is opening up unexpected scenarios in cancer genetics. When analyzed for their systemic properties, these genes show a general fragility towards perturbation. A recent paper published in BMC Biology shows how the founder domains of known cancer genes emerged at two macroevolutionary transitions - the advent of the first cell and the transition to metazoan multicellularity.

See research article http://www.biomedcentral.com/1741-7007/8/66 webcite