Table 3

Motif relationships in nitrile hydratase leader peptide (NHLP) and Nif11-related protein (N11P) leader sequences to nitrile hydratase (NHase)

Accession

Description

Motif 1

Motif 2

Leader

Suffix


TIGR01847

Gram-positive leader

N/A

ELSEKELAQIIGG

23

41

TIGR03898

lichenicidin leader

IIRAWKDPEYRASLSSE

ELSDEELESITGG

47

30

TIGR03798

N11P

N/A

ELSDEELEAVAGG

69

23

TIGR03793

NHLP

IKKAWSDEEFKQALLNN

ELSDEQLDAVAGG

87

27

TIGR03795

NHLP-Burk

IALAWHDPEFRDELLAD

N/A

108

11

TIGR01323

NHase

VAKAWVDPEFKARLLKD

GLSEEQLAALVTR

193

16


Sequence similarities and motif positions in NHase alpha subunit and putative leader sequences. Residues shared by at least 70% of the calculated consensus sequences are shown in boldface. Leader peptide length is taken as the position of the C-terminal end of motif 2, averaged after the shortest 10% and longest 10% removed of each family are removed as outliers and possible gene call errors. The similarity of NHLP to N11P in motif 2 suggests intragenic recombination.

Haft et al. BMC Biology 2010 8:70   doi:10.1186/1741-7007-8-70

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