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Open Access Highly Accessed Commentary

Smart biomaterials - regulating cell behavior through signaling molecules

Aneta J Mieszawska* and David L Kaplan

Author Affiliations

Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA

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BMC Biology 2010, 8:59  doi:10.1186/1741-7007-8-59

Published: 19 May 2010

Abstract

Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior. Following the recent work of Mitchell and co-workers published in BMC Biology, we review how spatial and temporal control of signaling molecules in a matrix material regulates cellular responses for tissue-specific applications.

See research article http://www.biomedcentral.com/1741-7007/8/57 webcite