Table 1

Predicted prohormone and other cell-cell signaling peptides.

Prohormone/gene name

Gene symbol

Entrez gene ID

Ensembl_ID

Chicken Entrez ID

Chicken UniProt ID

MS


Adenylate cyclase activating polypeptide 1 (pituitary)

ADCYAP1

100225028

ENSTGUP00000010475

408251

P41534

Adrenomedullin

ADM

100231562

ENSTGUP00000008261

423042

na

-

Arginine vasopressin

AVP

100217635

ENSTGUP00000011316

396101

P24787

C-fos induced growth factor (vascular endothelial growth factor D)

FIGF

100227068

ENSTGUP00000008337

395255

Q8QGD7

-

C-RF amide peptide

CRF

100226474

na

420716

B0LF68

-

C-type natriuretic peptide 1

CNP1

100226912

na

na

A9CDT5

-

C-type natriuretic peptide 3

CNP3

na

ENSTGUP00000016882

419487

A9CDT6

-

Calcitonin-related polypeptide alpha

CALCA

100228652

ENSTGUP00000008761

396256

P10286

-

CART prepropeptide

CARTPT

100229332

na

na

na

-

Cholecystokinin

CCK

100190220

ENSTGUP00000004812

414884

Q9PU41

Chromogranin A (parathyroid secretory protein 1)

CHGA

100225869

ENSTGUP00000012975

423420

na

Chromogranin B (secretogranin 1)

CHGB

100230980

ENSTGUP00000002261

421312

na

Chromosome 12 open reading frame 39 (spexin)

C12orf39

na

ENSTGUP00000012483

na

na

-

Chromosome 2 open reading frame 40

C2orf40

100225694

ENSTGUP00000010030

771055

na

-

Corticotropin releasing hormone

CRHR1

100190638

ENSTGUP00000011624

404297

Q703P0

Endothelin 1

EDN1

100219314

ENSTGUP00000005994

420854

na

-

Endothelin 2

EDN2

na

ENSTGUP00000000838

419559

na

-

Endothelin 3

EDN3

100218153

ENSTGUP00000008244

768509

Q3MU75

-

Galanin prepropeptide

GAL

100229595

ENSTGUP00000010282

423117

P30802

-

Gastric inhibitory polypeptide

GIP

na

ENSTGUP00000014511

419989

A1DPK0

-

Gastrin-releasing peptide

GRP

na

ENSTGUP00000017765

425213

P01295

Ghrelin/obestatin prepropeptide

GHRL

na

na

408185

Q8AV73

-

Glucagon

GCG

100226588

ENSTGUP00000014141

396196

P68259

-

Glycoprotein hormones, alpha polypeptide

CGA

100227314

ENSTGUP00000012836

421829

Q6T5C1

-

Gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

GNRH1

100216318

ENSTGUP00000004488

770134

P37042

Growth hormone 1

GH1

100218808

ENSTGUP00000003400

378781

P08998

Growth hormone 1 (duplicate on Chr1)

GH1A

100232594

ENSTGUP00000013961

na

na

-

Growth hormone releasing hormone

GHRH

100218168

ENSTGUP00000005071

419178

Q1KNA7

-

Hypocretin (orexin) neuropeptide precursor

HCRT

100225610

ENSTGUP00000018297

374005

Q8AV17

*

Insulin

INS

100231606

ENSTGUP00000009610

396145

P67970

-

Insulin-like 5

INSL5

na

ENSTGUP00000010477

na

na

-

Insulin-like growth factor 1 (somatomedin C)

IGF1

100226283

ENSTGUP00000011633

418090

P18254

-

Insulin-like growth factor 2 (somatomedin A)

IGF2

100144432

ENSTGUP00000009618

395097

P33717

-

Islet amyloid polypeptide

IAPP

100230121

ENSTGUP00000012072

396362

Q90743

-

Mesotocin-neurophysin I

MST

100220528

ENSTGUP00000011315

768516

Q2ACD0

Motilin

MLN

100217914

ENSTGUP00000001847

768422

Q9PRP6

-

Natriuretic peptide precursor A

NPPA

100217781

ENSTGUP00000016155

395765

P18908

-

Neuromedin B

NMB

100222573

ENSTGUP00000004989

415333

A0MAR5

-

Neuromedin U

NMU

na

ENSTGUP00000007709

422748

P34963

-

Neuropeptide S

NPS

na

ENSTGUP00000011907

na

na

-

Neuropeptide VF precursor (gonadotropin-inhibitory hormone)

NPVF

100038821

ENSTGUP00000002951

378785

Q75XU6

Neuropeptide W

NPW

na

na

769277

na

-

Neuropeptide Y

NPY

100232180

ENSTGUP00000002889

396464

P28673

Neurotensin

NTS

100190409

ENSTGUP00000008164

417883

P13724

Osteocrin

OSTN

100230749

ENSTGUP00000009566

424907

A5JNH0

-

Pancreatic polypeptide

PPY

na

na

395564

P68248

-

Parathyroid hormone

PTH

100221585

ENSTGUP00000016235

396436

P15743

-

Parathyroid hormone-like hormone

PTHLH

100230763

ENSTGUP00000013060

396281

P17251

Platelet derived growth factor D

PDGFD

100221512

ENSTGUP00000013067

418978

na

-

Platelet-derived growth factor alpha polypeptide

PDGFA

100222155

ENSTGUP00000008778

374196

Q90WK2

-

Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

PDGFB

100228287

ENSTGUP00000010592

374128

Q90W23

-

Prepronociceptin

PNOC

na

na

422019

na

-

Pro-melanin-concentrating hormone

PMCH

100223423

ENSTGUP00000011636

418091

na

-

Prodynorphin

PDYN

na

na

na

na

-

Proenkephalin

PENK

100190068

ENSTGUP00000011453

421131

na

Prokineticin 2

PROK2

na

ENSTGUP00000010242

771674

na

-

Prolactin

PRL

na

ENSTGUP00000006544

396453

P14676

Prolactin B

PRLB

na

ENSTGUP00000006179

417800

C6ZDB7

-

Prolactin releasing hormone

PRLH

na

na

424018

A3RJ26

-

Proopiomelanocortin

POMC

100219426

ENSTGUP00000017296

422011

Q9YI93

Pyroglutamylated RFamide peptide

QRFP

100222487

na

771867

na

-

Relaxin 3

RLN3

100225505

ENSTGUP00000005181

427223

B1AC67

Secretin

SCT

100219077

ENSTGUP00000007375

423015

P01280

-

Secretogranin II (chromogranin C)

SCG2

100219534

ENSTGUP00000008135

424808

na

Secretogranin V (7B2 protein)

SCG5

100228713

ENSTGUP00000012091

769742

Q5ZI41

Somatostatin

SST

100219295

na

396279

P33094

Somatostatin 2

SST2

100221267

ENSTGUP00000017225

395106

Q7T2S6

-

Tachykinin, precursor 1

TAC1

100227778

ENSTGUP00000001703

420573

na

Thyroid-stimulating hormone beta

TSHB

100220136

ENSTGUP00000000984

395937

O57340

-

Thyrotropin-releasing hormone

TRH

100228179

ENSTGUP00000010894

414344

Q6ZXC3

-

Urocortin

UCN

na

na

na

na

Urocortin 3

UCN3

100221165

na

na

na

Urotensin 2

UTS2

100222633

ENSTGUP00000002613

404535

Q6Q2J6

-

Urotensin 2 domain-containing

UTS2D

100218300

ENSTGUP00000009562

404534

Q6Q273

-

Vascular endothelial growth factor C

VEGFC

100221203

ENSTGUP00000006624

422573

O57352 (quail)

-

Vasoactive intestinal peptide

VIP

100217965

ENSTGUP00000011533

396323

P48143


The list of 76 prohormone and signalling genes predicted from the survey of the zebra finch genome; information on gene name and identification are provided. In the mass spectrometry (MS) column, a check mark (√) indicates confirmation via MS, an asterisk (*) indicates their homologues are identified in other species and a dash (-) indicates no confirmation. Peptides from 24 predicted genes were detected by MS. The protein sequences of the discovered prohormone and signaling genes are provided in FASTA format [see Additional File 2].

Xie et al. BMC Biology 2010 8:28   doi:10.1186/1741-7007-8-28

Open Data