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Open Access Highly Accessed Research article

The IGF1 small dog haplotype is derived from Middle Eastern grey wolves

Melissa M Gray12*, Nathan B Sutter3, Elaine A Ostrander4 and Robert K Wayne1

Author Affiliations

1 Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA

2 Current Address: Laboratory of Genetics, University of Wisconsin, Madison, WI, USA

3 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA

4 Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

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BMC Biology 2010, 8:16  doi:10.1186/1741-7007-8-16

Published: 24 February 2010

Additional files

Additional file 1:

Supplemental Material. This PDF file contains the following: Figure S1: Neighbour-joining tree from insulin-like growth factor 1 (IGF1) dog derived genotyped single nucleotide polymorphisms (SNPs). Figure S2: Minimum spanning network of 6331 bps of phased sequence. Figure S3: Minimum spanning network of 4881 bps of phased sequence. Figure S4: Ancestral recombination graph of 6331 bps of phased sequence. Figure S5: Ancestral recombination graph of 4811 bps of phased sequence. Figure S6: Neighbour-joining tree based on 6331 bps of phased sequences from the 3' side of the recombination point. Figure S7: Neighbour-joining tree based on 4811 bps of phased sequences from the 3' side of the recombination point. Figure S8: Neighbour-joining tree based on sequences from the 5' side of the recombination point totaling 6331 bp. Figure S9: Neighbour-joining tree based on sequences from the 5' side of the recombination point totaling 4811 bp. Table S1: Sample datasets for domestic and wild canids used in each of five marker assays. Table S2: Dog-derived SNPs and sequence discovered SNPs and indels. Table S3: Sequenced amplicons across intron 2 of IGF1.

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Open Data

Additional file 2:

Dog-derived single nucleotide polymorphism (SNP) marker haplotypes based on 20 SNPs [15]. Counts are number of chromosomes. Greyed cells are the derived allele determined from golden jackal sequences. Bold haplotypes are small dog haplotypes. Italicized haplotypes are those with the least number of differences from small dog haplotype B.

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Open Data

Additional file 3:

Single nucleotide polymorphism haplotypes from sequenced regions of intron 2 (Figure 1). Counts are number of chromosomes. Grey vertical bar indicates a recombination point. Greyed cells are the derived allele determine from ancestral golden jackal sequences. Bold haplotypes are small dog haplotypes.

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Open Data

Additional file 4:

Matrix of single nucleotide polymorphism differences between haplotypes from 4811 bp of sequence. Bold haplotypes indicate small dog haplotypes. Bold numbers indicate haplotypes with smallest number of differences to the common small dog haplotype B.

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Open Data