Table 2

Cell cycle distribution in protein prostate cancer cell lines treated with 40 μM small molecule inhibitors of p27 depletion (SMIPs) for 24 and 48 h.

LNCaP

LNCaP

-S14

DU145

PC3

IMR90

Time

SMIP

G1

S

G2

G1

S

G2

G1

S

G2

G1

S

G2

G1

S

G2


24 h

DMSO

70.8

18.0

10.9

64.8

23.3

10.6

40.5

44.0

15.3

42.2

26.7

30.0

67.2

16.6

16.2

SMIP001

84.5

6.6

7.6

84.8

7.2

6.3

65.6

23.9

9.7

48.6

20.4

29.7

68.4

16.2

15.3

SMIP004

81.7

7.9

9.8

72.3

19.1

7.1

75.7

14.1

8.0

58.5

14.3

25.7

68.6

18.2

13.2

48 h

DMSO

70.4

17.8

10.0

66.4

22.3

7.5

50.7

29.8

17.7

46.3

20.8

31.2

77.0

12.8

10.3

SMIP001

83.6

8.5

6.6

86.8

6.9

3.5

71.1

13.4

13.6

57.5

13.6

27.8

77.0

8.9

14.1

SMIP004

87.3

3.5

6.6

75.8

14.7

6.4

79.7

9.0

10.4

65.8

8.5

24.3

77.6

11.5

10.9


The data is representative of two independent experiments.

Rico-Bautista et al. BMC Biology 2010 8:153   doi:10.1186/1741-7007-8-153

Open Data