Table 1 |
||
|
Cytotoxicity was analysed by MTT assay in LNCaP-S14 and IMR90 cells treated with increasing concentrations (0.01 - 40 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h. |
||
|
LNCaP-S14 |
IMR90 |
|
|
|
||
|
MG132 |
0.379 |
0.445 |
|
Thapsigargin |
0.0078 |
0.031 |
|
SMIP001 |
4.63 |
> 20 |
|
SMIP002 |
11.09 |
> 40 |
|
SMIP003 |
15.92 |
65.36 |
|
SMIP004 |
1.09 |
> 20 |
|
SMIP005 |
1.71 |
17.38 |
|
SMIP006 |
6.63 |
NT |
|
SMIP009 |
> 40 |
> 40 |
|
SMIP011 |
> 40 |
~ 40 |
|
SMIP012 |
4.59 |
~ 10 |
|
SMIP013 |
18.15 |
~ 20 |
|
SMIP015 |
13.02 |
~ 20 |
|
SMIP016 |
14.63 |
4.41 |
|
SMIP017 |
23.73 |
> 40 |
|
SMIP018 |
> 40 |
> 40 |
|
SMIP019 |
NT |
~ 40 |
|
|
||
|
NT: not tested. The data in the table represents the IC50 (μM). |
||
|
Rico-Bautista et al. BMC Biology 2010 8:153 doi:10.1186/1741-7007-8-153 |
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