Table 1

Cytotoxicity was analysed by MTT assay in LNCaP-S14 and IMR90 cells treated with increasing concentrations (0.01 - 40 μM) of the respective small molecule inhibitors of p27 depletion (SMIPs) for 72 h.

LNCaP-S14

IMR90


MG132

0.379

0.445

Thapsigargin

0.0078

0.031

SMIP001

4.63

> 20

SMIP002

11.09

> 40

SMIP003

15.92

65.36

SMIP004

1.09

> 20

SMIP005

1.71

17.38

SMIP006

6.63

NT

SMIP009

> 40

> 40

SMIP011

> 40

~ 40

SMIP012

4.59

~ 10

SMIP013

18.15

~ 20

SMIP015

13.02

~ 20

SMIP016

14.63

4.41

SMIP017

23.73

> 40

SMIP018

> 40

> 40

SMIP019

NT

~ 40


NT: not tested.

The data in the table represents the IC50 (μM).

Rico-Bautista et al. BMC Biology 2010 8:153   doi:10.1186/1741-7007-8-153

Open Data