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Open Access Research article

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

Nicolas Buchon*, Nichole A Broderick, Takayuki Kuraishi and Bruno Lemaitre*

Author Affiliations

Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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BMC Biology 2010, 8:152  doi:10.1186/1741-7007-8-152

Published: 22 December 2010

Additional files

Additional file 1:

Measurements of several parameters in the Drosophila gut following infection with Ecc15.

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Additional file 2:

Dynamics of the different cell populations in the midgut following infection with Ecc15.

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Additional file 3:

Transversal sections of guts from wild-type flies and flies with an altered level of EGFR pathway activity in enterocytes.

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Additional file 4:

The EGFR pathway is required for enterocyte delamination upon infection.

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Additional file 5:

Enterocytes undergoing delamination display marks of increased autophagy.

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Additional file 6:

The EGFR pathway is required in ISCs for the ISC proliferation induced by infection.

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Additional file 7:

Flies with a reduced level of EGFR pathway activity in ISCs display an increased susceptibility to Ecc15 infection.

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Additional file 8:

The EGFR ligands Spitz and Keren are expressed in the progenitor cells.

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Additional file 9:

The JAK/STAT pathway is activated in the visceral muscles.

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Additional file 10:

EGFR and JAK/STAT pathways synergize in ISCs to promote proliferation.

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Additional file 11:

Alteration of the EGFR pathway in enterocytes affects gut morphology.

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Additional file 12:

Flies with reduced EGFR activity in enterocytes are highly susceptible to oral infection with Ecc15.

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Additional file 13:

Ecc15 infection alters adherens junction dynamics in the gut.

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Additional file 14:

ISCs are in close proximity to visceral muscles.

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Additional file 15:

The EGFR pathway is required in both enteroblasts and enterocytes for proper morphogenesis.

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Additional file 16:

List of fly stocks used in this study.

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