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Open Access Highly Accessed Commentary

Zebrafish models of the immune response: taking it on the ChIn

Stephen A Renshaw1 and Philip W Ingham2*

Author Affiliations

1 MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK

2 Institute of Molecular and Cellular Biology, 61 Biopolis Drive, Proteos, Singapore 138673

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BMC Biology 2010, 8:148  doi:10.1186/1741-7007-8-148

Published: 22 December 2010

Abstract

The zebrafish is proving to be an extremely versatile new experimental model for unraveling the mysteries of innate immunity and has considerable promise as a system for the identification of novel modulators of this crucial biological process. A rate-limiting factor, however, is the mechanical stimulus required to induce the inflammatory response. A new chemically induced inflammation assay ('ChIn' assay) published in BMC Biology obviates this requirement and seems set to accelerate progress in the field.