Table 4

Pfam domains overrepresented in gene duplications associated with 2Ra

Domain name

Pfam ID

P value


PH domain

PF00169

8.85e-23

Homeobox domain

PF00046

5.42e-12

7 transmembrane receptor (rhodopsin family)

PF00001

1.17e-11

Tyrosine kinase domain

PF07714

1.84e-10

Serine/threonine kinase domain

PF00069

3.18e-10

PDZ

PF00595

4.30e-10

Intermediate filament protein

PF00038

1.02e-09

EGF-like domain

PF00008

3.39e-08

EF hand

PF00036

5.20e-08

Helix-loop-helix DNA-binding domain

PF00010

8.32e-08

SH3 domain

PF00018

8.80e-08

Ras family

PF00071

9.14e-08

Ion transport protein

PF00520

1.27e-07

SH2 domain

PF00017

1.30e-07

C2 domain

PF00168

4.48e-07

Neurotransmitter-gated ion channel ligand binding domain

PF02931

7.02e-07

Neurotransmitter-gated ion channel transmembrane region

PF02932

7.02e-07

Protein tyrosine phosphatase

PF00102

1.24e-06

RhoGEF domain

PF00621

1.24e-06

Calponin homology (CH) domain

PF00307

2.32e-06

7 transmembrane receptor (Secretin family)

PF00002

3.11e-06

SAM domain (Sterile α motif)

PF00536

3.11e-06

Protein kinase C terminal domain

PF00433

5.10e-06

Hormone receptor domain

PF02793

5.68e-06

RhoGAP domain

PF00620

6.71e-06

Fibronectin type III domain

PF00041

7.08e-06

IPT/TIG domain

PF01833

9.61e-06

Ligand-binding domain of nuclear

PF00104

1.84e-05

hormone receptor

Phosphotyrosine interaction domain (PTB/PID)

PF00640

2.75e-05

Phorbol esters/diacylglycerol binding domain (C1 domain)

PF00130

2.84e-05

Laminin G domain

PF02210

3.63e-05

E1-E2 ATPase

PF00122

7.87e-05


aAll Pfam domains overrepresented in gene duplications associated with 2ROs at the P value cutoff of 0.0001 can be linked with signal transduction. P values derive from the hypergeometric test. EGF, epidermal growth factor; PH domain, pleckstrin homology domain (PH domain); SH3, Src homology 3; SH2, Src homology 2; ig-like, plexins, transcription factors (IPT/TIG); phosphotyrosine-binding domain/phosphotyrosine interaction domain (PTB/PID).

Huminiecki and Heldin BMC Biology 2010 8:146   doi:10.1186/1741-7007-8-146

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