Table 3

Top 20 biological processes associated with 2ROsa

ID

P value

Description


GO:0007165

2.12e-33

Signal transduction

GO:0007275

3.64e-26

Multicellular organismal development

GO:0007186

3.19e-19

G protein-coupled receptor protein signalling pathway

GO:0006468

1.13e-15

Protein amino acid phosphorylation

GO:0007154

1.10e-13

Cell communication

GO:0007268

7.50e-13

Synaptic transmission

GO:0022008

2.34e-12

Neurogenesis

GO:0030036

1.64e-11

Actin cytoskeleton organization and biogenesis

GO:0050877

2.07e-11

Neurological system process

GO:0006811

3.47e-11

Ion transport

GO:0051056

8.93e-11

Regulation of small GTPase-mediated signal transduction

GO:0006928

1.52e-10

Cell motility

GO:0009605

1.95e-10

Response to external stimulus

GO:0006796

2.60e-10

Phosphate metabolic process

GO:0050794

4.15e-10

Regulation of cellular process

GO:0007265

7.20e-10

Ras protein signal transduction

GO:0000904

8.59e-10

Cellular morphogenesis during differentiation

GO:0006813

1.04e-09

Potassium ion transport

GO:0051179

1.63e-09

Localization

GO:0048812

1.77e-09

Neurite morphogenesis


aSignal transduction is the top overrepresented term: Almost three quarters of human genes associated with this term are marked as 2R-ohnologs (2ROs). P values derive from the hypergeometric test with conditional correction taking into account the hierarchical structure of ontologies.

Huminiecki and Heldin BMC Biology 2010 8:146   doi:10.1186/1741-7007-8-146

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