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How the vertebrates were made: selective pruning of a double-duplicated genome

Gerard Manning* and Eric Scheeff

Author affiliations

Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA

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Citation and License

BMC Biology 2010, 8:144  doi:10.1186/1741-7007-8-144

Published: 13 December 2010


Vertebrates are the result of an ancient double duplication of the genome. A new study published in BMC Biology explores the selective retention of genes after this event, finding an extensive enrichment of signaling proteins and transcription factors. Analysis of their expression patterns, interactions and subsequent history reflect the forces that drove their evolution, and with it the evolution of vertebrate complexity.

See research article: webcite