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Open Access Highly Accessed Research article

A metabolic signature of long life in Caenorhabditis elegans

Silke Fuchs12, Jacob G Bundy3, Sarah K Davies1, Jonathan M Viney4, Jonathan S Swire5 and Armand M Leroi1*

Author Affiliations

1 Division of Biology, Silwood Park Campus, Imperial College London, SL5 7PY, UK

2 Current address: Division of Cell and Molecular Biology, South Kensington Campus, Imperial College London, London SW7 2AZ, UK

3 Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, South Kensington Campus, Imperial College London, London SW7 2AZ, UK

4 National Heart and Lung Institute, South Kensington Campus, Imperial College, London, London SW7 2AZ, UK

5 Centre for Bioinformatics, Division of Molecular Biosciences, South Kensington Campus, Imperial College London, London SW7 2AZ, UK

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BMC Biology 2010, 8:14  doi:10.1186/1741-7007-8-14

Published: 10 February 2010

Additional files

Additional file 1:

Table S1. Metabolite concentrations in long-lived and normal worms based on manual computer-aided fitting to 1H NMR spectra (see Materials and Methods for further details).

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Additional file 2:

Table S2. Expression of genes encoding enzymes in selected metabolic pathways. Relative expression in daf-2(e1370) adults compared to wild-type worms; data from reference [20].

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Additional file 3:

Table S3. List of assigned metabolites detected in worm samples by 1D NMR, and associated resonance chemical shifts and multiplicity. Only the most characteristic resonances are listed in the table.

Format: PDF Size: 39KB Download file

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Open Data