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Open Access Research article

An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian

Savita Ayyar1, Barbara Negre1, Pat Simpson1 and Angelika Stollewerk2*

Author Affiliations

1 Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK

2 School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK

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BMC Biology 2010, 8:127  doi:10.1186/1741-7007-8-127

Published: 24 September 2010

Additional files

Additional file 1:

asense rescue experiment. Comparison of the number of stout bristles exhibiting differentiation defects in ase1 flies (first column) and ase1 flies carrying hsp70Gal4 > UAS Dm-sc, hsp70Gal4 > UAS Dm-ase, hsp70Gal4 > UAS Tc-ase and hsp70-Gal > UAS-CsASH2 transgenes

Format: PDF Size: 11KB Download file

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Open Data

Additional file 2:

Alignment of the SOP enhancer elements. Nucleotide sequence alignments of the individual transcription factor binding sites of Drosophila, Tribolium, Daphnia, Strigamia and Cupiennius.

Format: PDF Size: 30KB Download file

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Open Data

Additional file 3:

Sequence logos of the SOPE boxes. Graphic representation of the aligned sequences of the SOPE binding sites of Drosophila melanogaster, Tribolium castaneum, Daphnia pulex, Strigamia maritima and Cupiennius salei.

Format: PDF Size: 59KB Download file

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Open Data

Additional file 4:

Misexpression experiment. Comparison of the number of ectopic bristles in flies carrying the UAS-ase/ASH2 ORF only and ORF+SOPE constructs.

Format: PDF Size: 12KB Download file

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Open Data

Additional file 5:

SOP enhancer in the senseless 5' UTR. Arrangement of the SOPE boxes in the 5' UTR of the senseless transcript.

Format: PDF Size: 23KB Download file

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Open Data

Additional file 6:

Secondary structure of the ase-like UTRs. Graphic representation of the secondary structure of the UTRs of the Drosophila melanogaster, Tribolium castaneum and Daphnia pulex asense genes and the UTRs of Strigamia maritima ASH and Cupiennius salei CsASH2.

Format: PDF Size: 595KB Download file

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Open Data