Krüppel-like transcription factors and control of pluripotency
1 Inserm U846, 18 avenue Doyen Lépine, 69500 Bron, France
2 Stem Cell and Brain Research Institute, 69500 Bron, France
3 Université de Lyon, Université Lyon 1, 69003, Lyon, France
BMC Biology 2010, 8:125 doi:10.1186/1741-7007-8-125Published: 27 September 2010
Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency.