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Open Access Commentary

Krüppel-like transcription factors and control of pluripotency

Pierre-Yves Bourillot123 and Pierre Savatier123*

Author Affiliations

1 Inserm U846, 18 avenue Doyen Lépine, 69500 Bron, France

2 Stem Cell and Brain Research Institute, 69500 Bron, France

3 Université de Lyon, Université Lyon 1, 69003, Lyon, France

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BMC Biology 2010, 8:125  doi:10.1186/1741-7007-8-125

Published: 27 September 2010

Abstract

Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency.

See research article http://www.biomedcentral.com/1741-7007/8/128 webcite