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Open Access Highly Accessed Commentary

Oestrogen shuts the door on SOX9

Lindsey Mork and Blanche Capel*

Author affiliations

Department of Cell Biology, Duke University Medical Center, Durham, NC, USA

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Citation and License

BMC Biology 2010, 8:110  doi:10.1186/1741-7007-8-110

Published: 31 August 2010

Abstract

Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing nuclear localization of SOX9, a master regulator of the testis differentiation pathway.

See research article http://www.biomedcentral.com/1741-7007/8/113 webcite