Oestrogen shuts the door on SOX9
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BMC Biology 2010, 8:110 doi:10.1186/1741-7007-8-110Published: 31 August 2010
Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing nuclear localization of SOX9, a master regulator of the testis differentiation pathway.