Kinesin-14: the roots of reversal
Centre for Mechanochemical Cell Biology, Warwick University Medical School, Gibbet Hill, Coventry CV4 7AL, UK
BMC Biology 2010, 8:107 doi:10.1186/1741-7007-8-107Published: 16 August 2010
Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.