Insulators and imprinting from flies to mammals
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BMC Biology 2010, 8:104 doi:10.1186/1741-7007-8-104Published: 30 July 2010
The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible for maintaining the imprinted state in Drosophila may be evolutionarily conserved and that CTCF may also play a critical role in this process.