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Open Access Commentary

Insulators and imprinting from flies to mammals

Chunhui Hou and Victor G Corces*

Author Affiliations

Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA 30322, USA

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BMC Biology 2010, 8:104  doi:10.1186/1741-7007-8-104

Published: 30 July 2010


The nuclear factor CTCF has been shown to be necessary for the maintenance of genetic imprinting at the mammalian H19/Igf2 locus. MacDonald and colleagues now report in BMC Biology that the mechanisms responsible for maintaining the imprinted state in Drosophila may be evolutionarily conserved and that CTCF may also play a critical role in this process.

See research article webcite