The effect of deletion of THOC5/FMIP on hematopoiesis. Six-week-old Mx-cre THOC5/FMIP (flox/flox) mice (Mx cre +, n = 9) and THOC5/FMIP (flox/flox) mice (Mx-cre -, n = 6) were injected with poly (I:C) (250 μg each) and blood was taken from the tail vein on zero, four and seven days after the first poly (I:C) injection. In addition, 10-13 days after poly (I:C) injection blood samples from Mx-cre THOC5/FMIP (flox/flox) mice (n = 3) which show severe symptom and control THOC5/FMIP (flox/flox) (n = 3) mice were taken from tails. Samples were analyzed on an ABC Vet automated blood counter. Wbc = white blood cells (103/mm3); Plt = platelets (103/mm3); Rbc = red blood cells (106/mm3); Hgb = hemoglobin (g/dl); Hct = hematocrit (%).
Mancini et al. BMC Biology 2010 8:1 doi:10.1186/1741-7007-8-1