Table 2

Highly regulated proteins

Biological process

Protein

1 day

4 days

7 days


Signaling associated

CCDC88C

1.52

2.03

2.37


GPR109B

2.38

1.61

2.65


INVS

-1.71

1.32

2.57


IRS4

2.06

2.09

2.56


ISYNA1

2.20

1.64

2.59


ITSN2

2.86

1.96

2.32


NET1

2.06

1.61

2.76


NOS1

4.93*

1.91

1.16


OR2AT4

1.67

138

2.01


WNT8A

1.74

1.65

2.43


Ca2+ binding and translocation

ATP11A

1.21

196

2.72


HAK

-1.43

-1.06

2.37


PVALB

-1.16

-1.35

-2.56


SLC25A24

-1.71

1.32

2.57


Transcription and translation

CWC15

-1.26

-1.74

-3.33*


DDX46

1.18

-1.23

-2.22


JMJD1B

-1.05

-1.67

-6.82


MNT

1.11

-1.26

-2.39


NR2C2

2.32

2.06

2.05


RPL7L1

2.47

1.54

1.17


RPS20

1.63

1.80

3.61*


ZNF777

-2.58

-2.23

-1.43


Cytoskeleton

FHDC1

-1.22

-1.45

-2.06


MYL3

-1.49

-1.62

-2.06


MYL5

-1.45

-1.69

-2.04


MYO1e

2.44

-1.05

NC


MYO9A

2.21

NC

NC


NAV1

1.42

1.45

2.11


PMFBP1

2.86

1.96

2.32


SORBS1

-1.22

-1.57

-2.20


ST3GAL5

2.07

1.87

1.96


SYNE2

-1.68

1.20

2.67


TM7

-1.17

-1.45

-2.10


TNNT3A

-1.17

-1.71

-2.01


Extracellular matrix

COL13A1

1.41

1.49

2.66


FGB

3.39*

1.63

1.14


FGG

4.64*

2.17

1.14


TINAG

-1.68

-2.01

-2.77


Metabolism

DAGLB

3.88*

1.26

1.49


DHRS4

4.45*

3.93*

4.21*


Cell protection

CYP2F1

-1.24

-1.55

-2.42


Degradation

TMPRSS9

-1.07

-1.70

-6.95*


Cell cycle

EVI5

4.00*

3.29*

3.85*


Priority 1 and 2 proteins upregulated or downregulated by a value of 2.00 or more on one or more days post amputation (dpa). Asterisks indicate exceptionally high values (over 3.00) on one or more dpa.

Rao et al. BMC Biology 2009 7:83   doi:10.1186/1741-7007-7-83

Open Data