Table 4

Multivariate Models with Covariates for Alcohol Consumption

MONTREAL (r2 = 0.62)

Effect

Estimate

Standard Error

t-statistic

p-value

Intercept

-0.59

0.13

-4.59

<.0001

recessive haplotype 2 - MPDZ

1.02

0.24

4.17

<.0001

rs701492 - GAD1 (AA)

0.70

0.10

6.94

<.0001

rs701492 - GAD1 (AB)

-0.03

0.07

-0.42

0.6714

rs701492 - GAD1 (BB)

referent

Age

0.01

0.00

4.50

<.0001

Alcohol dependence in past year

1.04

0.10

10.73

<.0001

Alcohol abuse in past year

0.73

0.10

7.67

<.0001

Family history of depression (1st degree relative)

0.50

0.09

5.45

<.0001

Familial depression and alcohol dependence*

-0.85

0.14

-6.09

<.0001

Used medication other than antidepressants in last month

0.26

0.07

3.91

0.0001

SYDNEY (r2 = 0.62)

Effect

Estimate

Standard Error

t-statistic

p-value

Intercept

0.24

0.06

4.12

<.0001

CHRM5 (recessive)

2.10

0.35

5.95

<.0001

GABRB2 (dominant)

3.03

0.43

7.00

<.0001

PPP1R1B (recessive)

2.97

0.32

9.22

<.0001

Alcohol dependence in past year

0.58

0.11

5.06

<.0001

Alcohol abuse in past year

0.58

0.11

5.14

<.0001


Shown are the coefficients associated with the final multivariate models with covariates for alcohol consumption as outcome. Final models were chosen using a backward selection process with an exit criterion of p > 0.001.

* Familial depression is defined as major depression in the subject and in a first-degree relative.

Tabakoff et al. BMC Biology 2009 7:70   doi:10.1186/1741-7007-7-70

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