Table 3

Genetic (SNP) Associations with Alcohol Consumption: WHO/ISBRA Subjects

refSNP ID

Location Within Gene

Chr

Basepair

minor allele/major allelea

MAF (Males/Females)

unadjusted p-value

FDR


MONTREAL


rs2241165

intronic region of GAD1

2

171386625

C/T

0.25/0.23

0.0001

0.0400


rs701492

intronic or downstream region of GAD1

2

171410726

T/C

0.31/0.31

<0.0001

0.0018


rs7578661

intronic region of GAD1

2

171423379

G/C

0.31/0.31

<0.0001

0.0018


rs1389752

intronic region of MPDZ

9

13225287

A/T

0.14/0.15

<0.0001b

0.0130b


SYDNEY


rs8030094

intronic region of CHRM5

15

32124174

A/G

0.18/NA

0.0002

0.0326


rs10051667

intronic region of GABRB2

5

160830906

C/T

0.09/NA

<0.0001

0.0110


rs9607272

intronic region of MAPK1 and TUBA8c

22

20466398

G/T

0.19/NA

<0.0001

0.0062


rs879606

upstream region of PPP1R1B

17

35035375

A/G

0.13/NA

<0.0001

0.0062


Significant results from univariate association analysis with alcohol consumption. Shown are the eight SNPs that showed a significant (FDR<0.05) association with alcohol consumption (g/kg/day) in a genotype model.

aMinor and major allele designation is according to Ensembl release 50.

bThis SNP was significant when both genders are combined; in male subjects, the FDR for this SNP was 0.09. All other SNPs shown were significant when males only were tested.

cThe localization of this SNP is ambiguous. Its presence in MAPK1 and the overlapping gene, TUBA8 (tubulin alpha 8) is of particular interest, given the findings of differences in expression of cytoskeletal genes in the HXB/BXH rat strains.

Tabakoff et al. BMC Biology 2009 7:70   doi:10.1186/1741-7007-7-70

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